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- https://www.nature.com/articles/s41467-024-53105-8De novo protein sequencing of antibodies for identification of ...
Oct 10, 2024 ... Matching the MS data with the sequence database produced by B cell repertoire sequencing helps discover antigen-specific antibodies. This ...
- https://pubs.acs.org/doi/10.1021/acs.jproteome.1c00169Mass Spectrometry-Based De Novo Sequencing of Monoclonal ...
Jun 14, 2021 ... Most MS-based strategies for antibody sequencing rely on a proteomics-type bottom-up liquid chromatography-tandem mass spectrometry (LC-MS/MS) ...
- https://www.rapidnovor.com/services/antibody-sequencing/Antibody Sequencing Service - Amino Acid Sequence in 2 Weeks
Jan 22, 2025 ... Protein de novo Antibody Sequencing determines the amino acid sequence of monoclonal antibodies using mass spectrometry. Our proprietary ...
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256418/Mass Spectrometry-Based De Novo Sequencing of Monoclonal ...
Antibody sequences are typically obtained through cloning and sequencing of the coding mRNAs of the paired heavy and light chains. ... The sequencing workflows ...
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9225641/A perspective toward mass spectrometry-based de novo sequencing ...
Jun 14, 2022 ... A key step in therapeutic and endogenous humoral antibody characterization is identifying the amino acid sequence.
- https://www.biorxiv.org/content/10.1101/2024.11.11.622451v1Systematic benchmarking of mass spectrometry-based antibody ...
Nov 12, 2024 ... Scientists have systematically evaluated the reliability and efficiency of mass spectrometry in antibody sequencing, which is crucial for immune ...
- https://pubmed.ncbi.nlm.nih.gov/34121409/Mass Spectrometry-Based De Novo Sequencing of Monoclonal ...
Jul 2, 2021 ... Antibody sequence information is crucial to understanding the structural basis for antigen binding and enables the use of antibodies as ...
- https://www.sciencedirect.com/science/article/pii/S0167779921001931Progress and challenges in mass spectrometry-based analysis of ...
Current knowledge gaps in antibody repertoire biology that can be resolved by mass spectrometry (MS) analysis of antibody sequences (Ab-seq) include reliable ...
- https://pubmed.ncbi.nlm.nih.gov/37499263/Direct Mass Spectrometry-Based Detection and Antibody ...
Sep 1, 2023 ... Direct Mass Spectrometry-Based Detection and Antibody Sequencing of Monoclonal Gammopathy of Undetermined Significance from Patient Serum: A ...
- https://www.life-science-alliance.org/content/7/6/e202302366Reverse-engineering the anti-MUC1 antibody 139H2 by mass ...
Mar 20, 2024 ... Here, we report direct mass spectrometry–based sequencing of anti-MUC1 hybridoma-derived 139H2 IgG, enabling reverse-engineering of the functional recombinant ...